DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development.

Keith D Harris James P B Lloyd Katherine Domb Daniel Zilberman Assaf Zemach

Published in: Epigenetics & chromatin (2019)

Based on these results, we propose that gene body CG methylation can oscillate during development if it is kept to a level adequate to preserve function. Additionally, our data suggest that heightened non-CG methylation is a conserved regulator of animal nervous systems.

Keyphrases

dna methylation
genome wide
copy number
transcription factor
gene expression
electronic health record
machine learning
big data
deep learning
data analysis