Lifetime Stressful Events Associated with Alzheimer's Pathologies, Neuroinflammation and Brain Structure in a Risk Enriched Cohort.

Eleni PalpatzisMuge AkinciPablo Aguilar-DominguezMarina Garcia-PratKaj BlennowHenrik ZetterbergMargherita CarboniGwendlyn KollmorgenNorbert WildKarine FauriaCarles FalconJuan Domingo GispertMarc Suarez-CalvetOriol Grau-RiveraGonzalo Sánchez-BenavidesEider M Arenaza-Urquijonull null

Published in: Annals of neurology (2024)

We did not find evidence supporting the association of total SLEs with AD, neuroinflammation, and atrophy pathways. Instead, the associations appear to be contingent on events occurring during early and midlife, sex and history of psychiatric disease. ANN NEUROL 2024.

Keyphrases

cerebral ischemia
lipopolysaccharide induced
traumatic brain injury
lps induced
cognitive impairment
mental health
white matter
subarachnoid hemorrhage
inflammatory response
resting state
brain injury
blood brain barrier
multiple sclerosis
neural network
breast cancer risk