The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man.
Charles BridgewoodAdewonuola AlaseAbdulla WatadMiriam WittmannRichard CuthbertDennis McGonaglePublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
We report that this cytokine shows no activity in human cells. IL-39 chimera protein failed to induce either IL-6, IL-8, TNF, or IL-17A from leukocytes or STAT3 phosphorylation and thus, remains a 'theoretical cytokine' in humans.
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