Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.
Rong YeClaire O'CallaghanCatarina RuaFrank H HezemansNegin HollandMaura MalpettiP Simon JonesRoger A BarkerCaroline H Williams-GrayTrevor W RobbinsLuca PassamontiJames Benedict RowePublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
The relationship between LC and nonmotor symptoms highlights a role for noradrenergic dysfunction across both PD and PSP, confirming the potential for noradrenergic therapeutic strategies to address transdiagnostic cognitive and behavioral features in neurodegenerative disease. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- magnetic resonance imaging
- parkinson disease
- contrast enhanced
- oxidative stress
- simultaneous determination
- mass spectrometry
- mild cognitive impairment
- systematic review
- white matter
- diffusion weighted imaging
- human health
- multiple sclerosis
- depressive symptoms
- sleep quality
- magnetic resonance
- high resolution
- liquid chromatography
- deep brain stimulation
- high resolution mass spectrometry