Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease.
Yohei YamaguchiTomoko Kurita-OchiaiRyoki KobayashiToshihiko SuzukiTomohiro AndoPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2016)
Porphyromonas gingivalis activated innate immune cells via the NLRP3 inflammasome. These results suggest that the NLRP3 inflammasome, followed by a response from the IL-1 family, is critical in periodontal disease induced by wild-type P. gingivalis challenge via sustained inflammation.