The Ameliorative Impact of Centella asiatica on the Working Memory Deficit in Streptozotocin-induced Rat Model of Alzheimer Disease.
Razyeh SahraeiSamaneh AminyavariMehran HosseiniMohammad Mehdi Hassanzadeh-TaheriMohsen FoadoddiniMohammad Reza SaebipourPublished in: Basic and clinical neuroscience (2022)
(CA) is widely used in different traditional medicine systems for various purposes, such as reducing blood pressure, memory enhancement, and promoting longevity. In the present study, we tested the possible impact of CA leaf and stem extract in an animal model of memory damage. Memory impairment was induced in adult rats by intracerebral infusion of a neurotoxin chemical. Then, the memory-impaired animals were orally treated with 150-300 mg/kg of CA extract for 21 days. Finally, we tested their working memory by placing them in a Y-maze apparatus. Furthermore, their most involved brain part (hippocampus) was dissected, and its cell density was evaluated. Our findings exhibited that CA treatment considerably improved rats' memory performance, indicating by enhancing working memory score in the Y-maze task. In addition, CA treatment significantly prevented neuronal cell loss in the hippocampus of memory-impaired rats. This study shows that CA has beneficial effects on memory and cognitive function.
Keyphrases
- working memory
- transcranial direct current stimulation
- attention deficit hyperactivity disorder
- blood pressure
- diabetic rats
- oxidative stress
- single cell
- protein kinase
- cell therapy
- metabolic syndrome
- low dose
- cerebral ischemia
- high glucose
- heart rate
- adipose tissue
- young adults
- mild cognitive impairment
- combination therapy
- blood brain barrier