Accuracy of Transient Elastography in Assessing Fibrosis at Diagnosis in Naïve Patients With Primary Biliary Cholangitis: A Dual Cut-Off Approach.
Laura CristoferiVincenza CalvarusoDiletta OveriMauro ViganòCristina RigamontiElisabetta DegasperiVincenzo CardinaleSara LabancaNicola ZucchiniAnna FicheraVito Di MarcoMonica LeutnerRosanna VenereAntonino PicciottoMartina LucàGiacomo MulinacciAndrea PalermoAlessio GerussiDaphne D'AmatoSarah Elisabeth O'DonnellFederica CeriniCarla De BenedittisFederica MalinvernoVincenzo RoncaClara MancusoNora CazzagonAntonio CiaccioDonatella BarisaniMarco MarzioniAnnarosa FloreaniDomenico AlvaroEugenio GaudioPietro InvernizziCarpino GuidoAlessandra NardiMarco Carbonenull nullPublished in: Hepatology (Baltimore, Md.) (2021)
In a multicenter study of treatment-naïve PBC patients, we identified two cutoffs (LSM ≤6.5 and >11.0 kPa) able to discriminate at diagnosis the absence or presence, respectively, of AF in PBC patients, with external validation. In patients with LSM between these two cutoffs, VCTE is not reliable and liver biopsy should be evaluated for accurate disease staging. BMI and liver biochemistry did not affect LSMs.