Targeting G9a/DNMT1 methyltransferase activity impedes IGF2-mediated survival in hepatoblastoma.

Salih DemirNegin RazizadehÉmilie IndersieSophie BranchereauStefano Cairo Roland Kappler

Published in: Hepatology communications (2024)

The inhibition of UHRF1-associated epigenetic traces, such as IGF2-mediated survival, is an attractive approach to treat high-risk HB, especially when combined with the standard-of-care therapeutic cisplatin.

Keyphrases

dna methylation
healthcare
binding protein
free survival
gene expression
palliative care
pi k akt
quality improvement
growth hormone
drug delivery