Sensitive detection of topiramate degradation products by high-performance liquid chromatography/electrospray ionization mass spectrometry using ion-pairing reagents and polarity switching.
Eduardo Costa PintoChengdong XuLucio Mendes CabralDaniel W ArmstrongValéria Pereira de SousaPublished in: Rapid communications in mass spectrometry : RCM (2019)
Two new alternative MS approaches for analyzing the main degradation products of topiramate were developed. The proposed methods are considered advantageous over the existing methods and can be applied to quality control studies of topiramate.
Keyphrases
- high performance liquid chromatography
- mass spectrometry
- sensitive detection
- quality control
- liquid chromatography
- tandem mass spectrometry
- quantum dots
- gas chromatography
- solid phase extraction
- simultaneous determination
- capillary electrophoresis
- ms ms
- multiple sclerosis
- loop mediated isothermal amplification
- case control