Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine Adipose-Derived Stromal Cells (ASCs)' Metabolic Functions and Negatively Regulates their Basal Adipogenic Potential.

Lynda BourebabaMagdalena ZyzakMateusz SikoraAnna Serwotka-SuszczakMalwina MularczykMohamad Al NaemKrzysztof Marycz

Published in: Stem cell reviews and reports (2023)

Herein, we provide for the first time the evidence that SHBG protein in importantly involved in various key metabolic pathways governing EqASCs functions, and more importantly we showed that SHBG negatively affect the basal adipogenic potential of tested ASCs through a FABP4-dependant pathway, and provide thus new insights for the development of potential anti-obesity therapeutic approach in both animals and humans.

Keyphrases

metabolic syndrome
binding protein
type diabetes
human health
insulin resistance
risk assessment
small molecule
physical activity
protein protein
climate change
high fat diet induced