Werner Syndrome Associated with Poorly Differentiated Thyroid Carcinoma and Systemic Sclerosis-like Skin Manifestations: A Case Report.

Werner syndrome (WS) is an autosomal recessive disorder characterized by premature aging. WS patients often experience scleroderma-like manifestation including skin sclerosis and skin ulcer, making it difficult to differentiate WS from systemic sclerosis. Moreover, there is a high incidence of malignancy and arteriosclerosis-related disease in WS patients. We herein describe a 36-year-old woman with WS who had poorly differentiated thyroid carcinoma (PDTC), one of the rare phenotypes of thyroid tumor. This case suggested the importance to distinguish WS from systemic sclerosis and early diagnosis of malignancy.