Cell-penetrating peptide-mediated delivery of therapeutic peptides/proteins to manage the diseases involving oxidative stress, inflammatory response and apoptosis.
Issa SadeghianReza HeidariMohammad Javad RaeeManica NegahdaripourPublished in: The Journal of pharmacy and pharmacology (2022)
Totally, CPPs could potentially help to manage the diseases involving oxidative stress, inflammatory response and apoptosis by delivering peptides/proteins that could selectively reach proper intracellular targets. More studies to overcome related CPP limitations and confirm the efficacy and safety of this strategy are needed before their clinical usage.
Keyphrases
- oxidative stress
- inflammatory response
- lipopolysaccharide induced
- lps induced
- diabetic rats
- induced apoptosis
- toll like receptor
- dna damage
- ischemia reperfusion injury
- endoplasmic reticulum stress
- single cell
- cell cycle arrest
- amino acid
- cell death
- cell therapy
- stem cells
- heat shock
- reactive oxygen species
- immune response
- case control
- signaling pathway
- pi k akt