Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy.
Ryotaro OnoueHiroyuki WatanabeMasahiro OnoPublished in: Chemical communications (Cambridge, England) (2023)
Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([ 125 I]BH) has been prepared as an Auger therapeutic agent. [ 125 I]BH showed high accumulation in the nucleus of HeLa cells and cytotoxicity caused by DNA double-strand breaks.
Keyphrases
- cancer therapy
- dna binding
- cell cycle arrest
- fluorescent probe
- induced apoptosis
- drug delivery
- living cells
- transcription factor
- cell death
- single molecule
- circulating tumor
- pi k akt
- water soluble
- signaling pathway
- oxidative stress
- cell proliferation
- nucleic acid
- mesenchymal stem cells
- electron microscopy
- circulating tumor cells