Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Lu TangHuan ZhangFen ZhouQiuzhe WeiMengyi DuJianghua WuChenggong LiWenjing LuoJie ZhouXindi WangZhaozhao ChenYinqiang ZhangZhongpei HuangZhuolin WuYuxi WenHuiwen JiangDanying LiaoHaiming KouWei XiongHeng MeiYu HuPublished in: Cancer communications (London, England) (2024)
These findings confirm that autophagy signaling in B-cell malignancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy.