A heteromultivalent host-guest sensor array for cell recognition and discrimination.

Xin-Yue HuZong-Ying HuJia-Hong TianLin ShiFei DingHua-Bin LiDong-Sheng Guo

Published in: Chemical communications (Cambridge, England) (2022)

We present a supramolecular sensor array based on a series of heteromultivalent macrocyclic coassemblies using amphiphilic calixarenes and cyclodextrin as the building blocks for cell recognition. The corresponding cross-reactivity between the coassemblies and cells served as the unique fingerprint for cell classification, and successfully identified the normal cell lines, cancerous cell lines, and cross-contaminated cells.

Keyphrases

induced apoptosis
cell therapy
cell cycle arrest
high resolution
machine learning
endoplasmic reticulum stress
stem cells
heavy metals
oxidative stress
bone marrow
risk assessment
mass spectrometry
mesenchymal stem cells
cell death
cell proliferation
capillary electrophoresis