Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity.
Katharina HerzogSimonetta BandieraSophie PernotCatherine FauvelleFrank JühlingAmélie WeissAnne BullSarah C DurandBéatrice Chane-Woon-MingSébastien PfefferMarion MerceyHervé LeratJean-Christophe MeunierWolfgang RaffelsbergerLaurent BrinoThomas F BaumertMirjam B ZeiselPublished in: Gut (2019)
miR-501-3p and miR-619-3p and their target OGT are previously undiscovered regulatory host factors for HCV assembly and infectivity. In addition to its effect on HCV morphogenesis, OGT may play a role in HCV-induced liver disease and hepatocarcinogenesis.