Inhibitory potency of the nettle lectin on neovascularization: a biomolecule for carbohydrate-mediated targeting of angiogenesis.
Esmaeil SamadianAbasalt Hosseinzadeh ColagarMahdieh SafarzadJahanbakhsh AsadiKamran MansouriPublished in: Molecular biology reports (2023)
Based on our findings, UDA may have an effect on cancer cell proliferation and vascularization events while causing minimal toxicity to normal cells via binding glyco-conjugates containing GlcNAc/man oligomers like EGFR. This is a blue clue for the angiogenesis-related therapeutic importance of UDA.
Keyphrases
- vascular endothelial growth factor
- cell proliferation
- endothelial cells
- induced apoptosis
- papillary thyroid
- small cell lung cancer
- cell cycle arrest
- cancer therapy
- epidermal growth factor receptor
- oxidative stress
- pi k akt
- tyrosine kinase
- squamous cell
- wound healing
- diabetic retinopathy
- squamous cell carcinoma
- cell death
- lymph node metastasis
- childhood cancer
- transcription factor
- dna binding
- tissue engineering
- binding protein
- oxide nanoparticles