Distribution of bacterial species and resistance patterns in surgical site infection after prior administration of vancomycin and tobramycin intrawound powdered antibiotic prophylaxis.

The use of local antibiotic prophylaxis resulted in no measurable increase in the proportion of infections caused by resistant bacterial pathogens after operative treatment of fractures. However, the small sample size and limited time frame of these preliminary data require continued investigation into their role as an adjunct to SSI prophylaxis.