Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

Lucia BorlleAbdo DerghamZacharie WundBrittany ZumboTeresa SouthardKelly R Hume

Published in: BMC veterinary research (2019)

We have developed two new feline sarcoma cell lines that can be used to study chemoresistance. We observed that salinomycin may potentiate (C10 cells) or work synergistically (SCCF1 cells) with doxorubicin in certain feline cancer cells. Further research is indicated to understand the mechanism of action of salinomycin in feline cancer cells as well as potential tolerability and toxicity in normal feline tissues.

Keyphrases

induced apoptosis
cell cycle arrest
cancer stem cells
oxidative stress
endoplasmic reticulum stress
gene expression
open label
climate change
study protocol