Obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland.

Bichen XueShulin WuChristina SharkeyShahin TabatabaeiChin-Lee WuZhipeng TaoZhiyong ChengDouglas W StrandAria F OlumiZongwei Wang

Published in: Prostate cancer and prostatic diseases (2020)

Our findings suggest that obesity-associated inflammation induces androgenic to estrogenic switch in the prostate gland, which may serve as an effective strategy for alternative therapies for management of lower urinary tract symptoms associated with BPH in select individuals.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
insulin resistance
oxidative stress
weight loss
metabolic syndrome
high fat diet induced
type diabetes
weight gain
prostate cancer
adipose tissue
estrogen receptor
body mass index