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Disrupting enzyme fluidity.
Ganesh Srinivasan Anand
Published in:
eLife (2021)
A combination of X-ray crystallography, NMR, and mass spectrometry has revealed how diverse small-molecule inhibitors bind Bruton's tyrosine kinase and alter the conformation of this enzyme.
Keyphrases
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tyrosine kinase
small molecule
high resolution
mass spectrometry
epidermal growth factor receptor
magnetic resonance
liquid chromatography
protein protein
single cell
solid state
gas chromatography
molecular dynamics simulations
magnetic resonance imaging
tandem mass spectrometry
electron microscopy