Emergence of plasmid-borne bla oxa-181 gene in Ochrobactrum intermedium: first report from India.
Thamaraiselvan ShanthiniPrasanth ManoharSagadevan SamnaRajendran SrividyaBülent BozdoğanRamesh Pathy ManianNachimuthu RameshPublished in: Access microbiology (2019)
Wastewater has become a potential habitat for multi-drug-resistant bacteria. The present study aims to screen for the presence of carbapenem-resistant bacteria in sewage water samples collected from hospital and non-hospital sources. From a total of 19 sewage water samples collected, 100 carbapenem-resistant non-lactose-fermenting Gram-negative bacteria (CR-NF-GNB) were isolated using MacConkey agar cultured with 8 mg l-1 of meropenem. On screening for beta-lactamase resistance genes (bla NDM, bla OXA-48-like, bla IMP, bla VIM and bla KPC), one isolate, Ochrobactrum intermedium , was found to carry the plasmid-borne bla OXA-48-like gene. To the best of our knowledge, we provide the first report of the rare and emerging opportunistic pathogen Ochrobactrum intermedium encoding the OXA-181 gene in its plasmid.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- multidrug resistant
- drug resistant
- gram negative
- acinetobacter baumannii
- genome wide
- genome wide identification
- healthcare
- copy number
- signaling pathway
- oxidative stress
- dna methylation
- immune response
- candida albicans
- transcription factor
- microbial community
- risk assessment
- drinking water
- adverse drug
- lps induced