Elevated neutrophil extracellular trap levels in periodontitis: Implications for keratinization and barrier function in gingival epithelium.

Ya-Yun CuiYi-Heng YangJia-Yi ZhengHui-Hui Ma Xue Han Chong-Shan Liao Min Zhou

Published in: Journal of clinical periodontology (2024)

This study indicates that NETs impair the barrier function of HGKs and suppress keratinization through ERK/KLF4 axis. These findings provide potential targets for therapeutic approaches in periodontitis to address impaired gingival keratinization.

Keyphrases

signaling pathway
cell proliferation
transcription factor
pi k akt
risk assessment
human health