Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex.
Dieke J van ReesPanagiota BoutiBart KleinPaul J H VerkuijlenMichel van HoudtKarin SchornagelAnton T J ToolDavid VenetChristos SotiriouSarra El-AbedMiguel IzquierdoSebastien GuillaumeCristina SauraSerena Di CosimoJens HuoberRebecca RoylanceSung-Bae KimTaco W KuijpersRobin van BruggenTimo K van den BergHanke L MatlungPublished in: Journal for immunotherapy of cancer (2022)
Our results support that neutrophil attack towards antibody-opsonized cancer cells by trogocytosis induces an active repair process by the exocyst complex in vitro. Our findings provide insight to the possible contribution of neutrophils in current antibody therapies and the tolerance mechanism of tumor cells and support further studies for potential use of the exocyst components as clinical biomarkers.
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