Redox-Neutral Decarboxylative and Desulfonylative C(sp 3 ) Trifluoromethylation: Method Development and Mechanistic Inquiry.

Sodium triflinate (CF 3 SO 2 Na) is an inexpensive bench-stable radical CF 3 source that is often activated by external oxidants such as peroxides. However, despite the commercial accessibility of CF 3 SO 2 Na, the salt has never been applied to decarboxylative trifluoromethylation due to challenges in controlled cross-radical coupling. We report a redox-neutral approach to decarboxylative C(sp 3 ) trifluoromethylation of carboxylic acid derivatives. Mechanistic inquiry is performed to address the limitations in scope.