SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism.

Romy Kronstein-WiedemannMarlena StadtmüllerSofia TraikovMandy GeorgiMadeleine TeichertHesham YosefJan WallenbornAndreas KarlKarin SchützeMichael WagnerAli El-ArmoucheTorsten Tonn

Published in: Stem cell reviews and reports (2022)

Our data identify RBC precursors as a direct target of SARS-CoV-2 and suggest that SARS-CoV-2 induced dysregulation in hemoglobin- and iron-metabolism contributes to the severe systemic course of COVID-19. This opens the door for new diagnostic and therapeutic strategies.

Keyphrases

sars cov
red blood cell
respiratory syndrome coronavirus
drug induced
early onset
diabetic rats
iron deficiency
oxidative stress
coronavirus disease
big data