Nurses working in rural acute and community-based settings are often asked for substance use treatment guidance and education in a health care system with minimal treatment services available. Nursing science provides an alternative answer for nurses to lean on in their clinical practice when working with rural-dwelling youth in the midst of substance misuse. Practical strategies are offered, which nurses may integrate into their routine clinical care to strengthen the nurse-patient relationship and enhance positive attributes among youth. Connective caring practice is essential to support rural youth well-being and recovery in the midst of substance misuse. [ Journal of Psychosocial Nursing and Mental Health Services, 62 (6), 7-11.].