Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells.

Muhammad Zubair Saleem Muhammad Azhar NisarMohammed AlshwmiSyed Riaz Ud DinYaser Gamallat Muhanmmad KhanTonghui Ma

Published in: OncoTargets and therapy (2020)

Taken together, Brv-A induces G2/M phase arrest, ROS-dependent apoptosis, ER stress, mitochondrial dysfunction and inhibits STAT3 activation in MCF-7 cells signifying it to be one of the potential anticancer therapeutics in future.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
breast cancer cells
cell cycle arrest
cell death
oxidative stress
dna damage
cell proliferation
reactive oxygen species
cell cycle
small molecule
current status
pi k akt
stress induced
signaling pathway
risk assessment
heat stress