Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma.
Dominic MaggioWinson S HoRebecca BreeseStuart WalbridgeHerui WangJing CuiJohn D HeissMark R GilbertJohn S KovachRongze O LuZhengping ZhuangPublished in: Journal of neuro-oncology (2020)
This is the first preclinical investigation of the effect of combining PP2A inhibition with PD1 blockade for GBM. This novel combination provided effective tumor immunotherapy and long-term survival in our animal GBM model.
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