CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation.
Raúl R Rodrigues-DíezAntonio Tejera-MuñozVanesa EstebanLasse Bach SteffensenRaquel Rodrigues-DíezMacarena OrejudoSandra Rayego-MateosLucas L FalkePablo Cannata-OrtizAlberto Ortiz ArduanJesus EgidoZiad MallatAna M BrionesM Auxiliadora BajoRoel GoldschmedingMarta Ruiz-OrtegaPublished in: Hypertension (Dallas, Tex. : 1979) (2021)
CCN2 is critically involved in the functional and structural homeostasis of the aorta and in maintenance of its integrity under Ang II-induced stress, at least, in part, by disruption of the aldosterone pathway. Thus, this study opens new avenues to future studies in disorders associated to vascular pathologies.