Extensively expanded murine-induced hepatic stem cells maintain high-efficient hepatic differentiation potential for repopulation of injured livers.

Bing YuHengyu LiJie ChenZhiying HeHaixiang SunGuangshun YangChangzhen ShangXin WangChuanjiang LiYajin ChenYiping Hu

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Extensively expanded iHepSCs can efficiently differentiate into hepatocytes in chemical defined medium. Transplantation of iHepSC-Heps was more effective and more efficient than transplantation of iHepSCs in Fah-/- mice. Our results suggested an innovative system to obtain sufficient hepatocytes through hepatic differentiation of iHepSCs generated by lineage reprogramming.

Keyphrases

stem cells
multidrug resistant
cell therapy
liver injury
drug induced
diabetic rats
metabolic syndrome
skeletal muscle
mesenchymal stem cells
wild type