Biodegradable Nanocomposite Antimicrobials for the Eradication of Multidrug-Resistant Bacterial Biofilms without Accumulated Resistance.
Ryan F LandisCheng-Hsuan LiAkash GuptaYi-Wei LeeMahdieh YazdaniNipaporn NgernyuangIsmail AltinbasakSanaa MansoorMuhammadaha A S KhichiAmitav SanyalVincent M RotelloPublished in: Journal of the American Chemical Society (2018)
Infections caused by multidrug-resistant (MDR) bacteria are a rapidly growing threat to human health, in many cases exacerbated by their presence in biofilms. We report here a biocompatible oil-in-water cross-linked polymeric nanocomposite that degrades in the presence of physiologically relevant biomolecules. These degradable nanocomposites demonstrated broad-spectrum penetration and elimination of MDR bacteria, eliminating biofilms with no toxicity to cocultured mammalian fibroblast cells. Notably, serial passaging revealed that bacteria were unable to develop resistance toward these nanocomposites, highlighting the therapeutic promise of this platform.
Keyphrases
- multidrug resistant
- reduced graphene oxide
- human health
- drug resistant
- gram negative
- acinetobacter baumannii
- candida albicans
- carbon nanotubes
- risk assessment
- drug delivery
- klebsiella pneumoniae
- induced apoptosis
- visible light
- gold nanoparticles
- drug release
- climate change
- cell cycle arrest
- quantum dots
- cell death
- big data
- signaling pathway
- cell proliferation
- highly efficient
- endoplasmic reticulum stress
- pseudomonas aeruginosa
- mass spectrometry
- high resolution
- aqueous solution
- simultaneous determination