Standard ganciclovir dosing results in slow decline of cytomegalovirus viral loads.
Anne-Grete MärtsonMarieke G G SturkenboomMarjolein KnoesterTjip S van der WerfJan-Willem C AlffenaarWilliam Hopenull nullPublished in: The Journal of antimicrobial chemotherapy (2022)
The developed linked PK/PD population model and subsequent PD simulations showed slow decline of CMV viral load and it appears that dosing of (val)ganciclovir in this study might have been inadequate to achieve fast reduction of viral load. It is clear that further studies are needed to specify the PD effects of ganciclovir by performing systematic measurements of both ganciclovir concentrations and CMV viral loads.