Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels.
Melissa E MurrayChristina M MoloneyNaomi KouriJeremy A SyrjanenBillie J MatchettDarren M RothbergJessica F TranovichTiffany N Hicks SirmansHeather J WisteBaayla D C BoonAivi T NguyenR Ross ReichardDennis W DicksonVal J LoweJeffrey L DageRonald C PetersenClifford R JackDavid S KnopmanPrashanthi VemuriJonathan Graff-RadfordMichelle M MielkePublished in: Molecular neurodegeneration (2022)
Higher soluble plasma p-tau levels may be the result of an intersection between insoluble deposits of amyloid-β and tau accumulation in brain, and may be associated with locus coeruleus degeneration.