Novel Twin-Crystal Nanosheets with MnO 2 Modification to Combat Bacterial Biofilm against Periodontal Infections via Multipattern Strategies.

Nowadays the multifunctional approaches to kill oral bacteria based on various nanocomposites have made great progress against periodontal infections, while the material structure and its functional integration are still insufficient. Herein, we proposed a therapeutic strategy of chemodynamical therapy (CDT) and photothermal therapy (PTT) in monocrystals to effectively enhance the synergistic treatment. The CuS/MnS@MnO 2 consisting of hexagonal CuS/MnS nano-twin-crystal with a shell layer of MnO 2 was developed. In this nanosystem, the purpose of synergistic treatment of periodontitis by combining PTT/CDT has been achieved within CuS/MnS monocrystal, where CuS served to achieve photothermal conversion, dissipate the biofilm and transfer the heat in situ to the integrated MnS, thus promoting the Mn 2+ -mediated CDT process. Meanwhile, the CDT process could generate the highly toxic hydroxyl radical to destroy extracellular DNA by utilization of endogenous H 2 O 2 produced by Streptococci in oral biofilm, cooperating with PTT to dissipate bacterial biofilm. With the design of outer shell of MnO 2 , the selective bacteria-killing can be realized by producing oxygen which can protect the periodontal non-pathogenic aerobic bacteria and threatened the survival of anaerobic pathogens Therefore, such design via multipattern strategies to combat microorganisms would provide a bright prospect for the clinical treatment of bacterial infections. This article is protected by copyright. All rights reserved.