Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis.

Chie MiyabeYoshishige MiyabeJun NagaiNoriko N MiuraNaohito OhnoJerold ChunRyoji TsuboiHiroshi UedaMasayuki MiyasakaNobuyuki MiyasakaToshihiro Nanki

Published in: Arthritis research & therapy (2019)

These results suggest that LPA-LPA1 signaling contributes to the development of vasculitis via chemoattractant production from endothelial cells followed by neutrophil recruitment. Thus, LPA1 has potential as a novel target for vasculitis therapies.

Keyphrases

endothelial cells
mouse model
binding protein