Cell-specific effects of nitric oxide on the efficiency and frequency of long distance contractions in murine colon.
Katharina BeckBarbara VoussenAmelie ReiglAlexander D VincentSean P ParsonsJan D HuizingaAndreas FriebePublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)
NO/cGMP signaling is critical for normal peristaltic movements; as NO-GC in both SMC and ICC is essential, both cell types appear to work in synchrony. The efficiency of contractions to expel fluid is particularly influenced by NO-GC in SMC.