The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes.
Phillip K WestAndrew N McCorkindaleBoris GuennewigThomas M AshhurstBarney ViengkhouEmina HayashidaSo Ri JungOleg ButovskyIain L CampbellMarkus J HoferPublished in: Journal of neuroinflammation (2022)
Our findings demonstrate that microglia responses to IL-6 and IFN-α are highly stimulus-specific, wide-ranging and give rise to divergent phenotypes that modulate microglia responses in neuroinflammatory and neurodegenerative diseases.