Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline versus Vancomycin in Healthy Volunteers.

Subjects given omadacycline had high fecal concentrations with a distinct microbiome profile compared to vancomycin. These pharmacokinetic and microbiome properties may help explain its low risk to cause Clostridioides difficile infection and warrant further research into its development as an antibiotic for Clostridioides difficile treatment.