mSphere of Influence: Metabolic redundancies enhance pathogenesis.
McKenzie K LehmanPublished in: mSphere (2024)
McKenzie Lehman works in the field of bacterial pathogenesis and metabolism. In this mSphere of Influence article, she reflects on how three papers entitled "Glycolytic dependency of high-level nitric oxide resistance and virulence in Staphylococcus aureus" by N. P. Vitko, N. A. Spahich, and A. R. Richardson (mBio 6:e00045-15, 2015, https://doi.org/10.1128/mbio.00045-15), "The Staphylococcus aureus cystine transporters TcyABC and TcyP facilitate nutrient sulfur acquisition during infection" by J. M. Lensmire, J. P. Dodson, B. Y. Hsueh, M. R. Wischer, et al. (Infect Immun 88:e00690-19, 2020, https://doi.org/10.1128/iai.00690-19), and "The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus " by C. F. Schuster, L. E. Bellows, T. Tosi, I. Campeotto, et al. (Sci Signal 16:ra81, 2016, https://doi.org/10.1126/scisignal.aaf7279) impacted her work on bacterial metabolism and pathogenesis.
Keyphrases
- staphylococcus aureus
- biofilm formation
- nitric oxide
- methicillin resistant staphylococcus aureus
- spinal cord injury
- rheumatoid arthritis
- pseudomonas aeruginosa
- protein kinase
- hydrogen peroxide
- nitric oxide synthase
- disease activity
- systemic sclerosis
- cystic fibrosis
- idiopathic pulmonary fibrosis
- antimicrobial resistance