Interventions to Prevent Sperm DNA Damage Effects on Reproduction.
Sandro C EstevesPublished in: Advances in experimental medicine and biology (2019)
Excessive oxidation and antioxidant imbalance resulting from several conditions may cause sperm DNA damage, which, in turn, affect male fertility, both natural and assisted. Sperm DNA damage transferred to the embryo might also affect the health of offspring. Several conditions associated with excessive oxidative stress are modifiable by the use of specific treatments, lifestyle changes, and averting exposure to environmental/occupational toxicants. Here, we discuss the strategies to reduce sperm DNA damage with a focus on clinical and surgical interventions.
Keyphrases
- dna damage
- oxidative stress
- dna repair
- physical activity
- weight gain
- healthcare
- metabolic syndrome
- ischemia reperfusion injury
- cardiovascular disease
- high fat diet
- type diabetes
- body mass index
- pregnant women
- induced apoptosis
- sensitive detection
- adipose tissue
- hydrogen peroxide
- anti inflammatory
- social media
- risk assessment
- climate change
- heat shock
- heat shock protein