Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons.
A GentileF De VitoD FresegnaF R RizzoS BullittaL GuadalupiV VanniF ButtariM Stampanoni BassiA LeutiV ChiurchiùG A MarfiaG MandolesiDiego CentonzeA MusellaPublished in: Neuropathology and applied neurobiology (2019)
These data highlight the synaptotoxic potential retained by MS T cells, suggesting that during the inflammatory phase of the disease infiltrating T cells could influence the neuronal activity contributing to the TNF-mediated mechanisms of glutamate excitotoxicity in central neurons.
Keyphrases
- multiple sclerosis
- end stage renal disease
- spinal cord
- ejection fraction
- newly diagnosed
- chronic kidney disease
- rheumatoid arthritis
- mass spectrometry
- prognostic factors
- ms ms
- oxidative stress
- electronic health record
- big data
- spinal cord injury
- white matter
- brain injury
- subarachnoid hemorrhage
- human health
- data analysis