Oxidized phosphatidylcholines are produced in renal ischemia reperfusion injury.
Zahra SolatiAndrea L EdelYue ShangKarmin OAmir RavandiPublished in: PloS one (2018)
We have shown for the first time that bioactive OxPC species are produced in renal I/R and their levels increase with increasing time of reperfusion in a kidney model of I/R and correlate with severity of I/R injury. Given the pathological activity of fragmented OxPCs, therapies focused on their reduction may be a mechanism to attenuate renal I/R injury.