Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach.

Jeffrey Amoako MensahKristina JohnsonChristopher A Reilly Karen S Wilcox Joseph E Rower Cameron S Metcalf

Published in: Epilepsia (2022)

The study demonstrates the utility of PK analyses for understanding the seizure protection time course in mice and rats. The data indicate that distinct PK profiles of ASMs between mice and rats likely drive differences in drug efficacy between rodent models.

Keyphrases

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