Performance evaluation of stool DNA methylation tests in colorectal cancer screening: a systematic review and meta-analysis.

Mahir GachabayovEdward LebovicsAram RojasDaniel Moritz FelsenreichRifat LatifiRoberto Bergamaschi

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)

Stool DNA methylation tests have high specificity (92%) with relatively lower sensitivity (81%). Combining genes increases sensitivity compared to single gene tests. The single most accurate gene is SDC2, which should be considered for further research.

Keyphrases

genome wide
dna methylation
copy number
colorectal cancer screening
genome wide identification
gene expression
genome wide analysis
high resolution
transcription factor