Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives.
Wafik ZakyJonathan L FinlayPublished in: Pediatric blood & cancer (2018)
Choroid plexus (CP) carcinoma is a rare pediatric brain neoplasm. Recent studies have highlighted the potential of genome-wide methylation and gene expression profiling to provide additional layers of information to improve tumor risk-stratification. There is a lack of data regarding the best therapy, and approaches have been heterogeneous. Despite multidisciplinary treatment approaches, the outcome remains guarded and treatments have been based on case series and expert opinions. In this study, we discuss the recent wealth of data regarding CP carcinoma molecular biology and current management. We also briefly highlight the remaining barriers to formulate the best treatment strategies, and future therapeutic potentials.
Keyphrases
- genome wide
- dna methylation
- copy number
- electronic health record
- big data
- ultrasound guided
- resting state
- gene expression
- white matter
- healthcare
- current status
- risk assessment
- genome wide identification
- machine learning
- functional connectivity
- human health
- artificial intelligence
- transcription factor
- cell therapy
- brain injury
- childhood cancer
- multiple sclerosis