Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy.

Nana LiZhi WangYongtai ZhangKai ZhangJianxu XieYing LiuWansi LiNianping Feng

Published in: Artificial cells, nanomedicine, and biotechnology (2018)

MSN/CUR-PEI-FA and MSN/CUR-HA were cytotoxic to MDA-MB-231 breast cancer cells. Both formulations showed an enhanced cellular uptake compared with that of a non-targeted nanocarrier, with a greater cellular uptake of FA-modified nanoparticles than that of HA-modified nanoparticles. Accordingly, MSN-PEI-FA showed more precise targeting and higher accumulation in tumours than did MSN-HA, as visualized by live imaging. Both types of nanoparticles had good biocompatibility and low toxicity, and MSN/CUR-PEI-FA inhibited the tumour growth to a greater degree than did free CUR. Thus, MSN/CUR-PEI-FA are a promising drug delivery system for the treatment of breast cancer.

Keyphrases

cancer therapy
breast cancer cells
drug delivery
high resolution
oxidative stress
stem cells
photodynamic therapy
anti inflammatory
hyaluronic acid
electron transfer