Dysregulation of genes and microRNAs in localized aggressive periodontitis.
Jussara Gonçalves FernandesLorri Ann MorfordPeter Lloyd HarrisonTheodora KompotiatiHong HuangIkramuddin AukhilShannon Margaret WalletLuciana Macchion ShaddoxPublished in: Journal of clinical periodontology (2020)
Most of the genes and miRNAs overexpressed here are directly or indirectly related to immune response and inflammation. This profile supports our previous findings that suggests LAP patients have a "hyper-responsive" phenotype upon activation of TLR pathway by periodontal pathogens.
Keyphrases
- immune response
- end stage renal disease
- genome wide
- ejection fraction
- chronic kidney disease
- newly diagnosed
- oxidative stress
- peritoneal dialysis
- bioinformatics analysis
- gene expression
- genome wide identification
- dendritic cells
- drug delivery
- dna methylation
- genome wide analysis
- patient reported
- multidrug resistant