Mitochondrial fumarate promotes ischemia/reperfusion-induced tubular injury.

Zuo-Lin LiMing-Min HuangMeng-Yao YuDi-Fei NieSha-Li FuJing-Jing DiTing LanBi-Cheng LiuQiu-Li Wu

Published in: Acta physiologica (Oxford, England) (2024)

Our studies demonstrated that the mitochondrial-derived fumarate promotes tubular epithelial cell injury in renal I/RI. Blockade of fumarate-mediated ROS/NF-κB signaling activation may serve as a novel therapeutic approach to ameliorate hypoxic tubule injury.

Keyphrases

high glucose
oxidative stress
signaling pathway
diabetic rats
endothelial cells
cell death
dna damage
lps induced
cell proliferation
drug induced
toll like receptor
case control