GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson's disease.

Chunyu LiYanbing HouRuwei OuQianqian WeiLingyu ZhangKuncheng LiuJunyu LinXueping ChenWei SongBi ZhaoYing WuHui Fang Shang

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2024)

These findings improve the current understanding of the genetic etiology of cognitive impairment in PD, and provide a novel target DPP6 to explore therapeutic options. Our results also demonstrate the potential to develop clinical-genetic model to identify patients susceptible to cognitive impairment and thus provide personalized clinical guidance.

Keyphrases

cognitive impairment
cognitive decline
genome wide
end stage renal disease
copy number
mild cognitive impairment
newly diagnosed
chronic kidney disease
prognostic factors
gene expression
human health
genome wide identification